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| カタログ番号 | HW313014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ARHGDIA Polyclonal Antibody (HW313014) is a rabbit polyclonal antibody detecting ARHGDIA in ELISA, IHC, WB. Suitable for Bovine, Human, Macaca fascicularis, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARHGDIA (Asn69-Asp204). | ||||||||
| ターゲット | Rho GDP-dissociation inhibitor 1, GDIA1, Rho GDI 1, Rho-GDI alpha, ARHGDIA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52565 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Rho GDP-dissociation inhibitor 1 (ARHGDIA) is a ~23 kDa protein. Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ARHGDIA polyclonal antibody at 1μg/ml on various samples.
Lane 1: HL-60 cell lysate
Lane 2: NIH3T3 cell lysate
Lane 3: Mouse lung lysate
Lane 4: Rat lung lysate
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