Anti-Human ARRB1 Recombinant Antibody (SAA2250) (HW793013)

Name: Anti-Human ARRB1 Recombinant Antibody (SAA2250)
Brand: abinScience
SKU: HW793013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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SDS

Vista general

Número de catálogo	HW793013
Reactividad de especies	Human
Aplicaciones	IP
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	SAA2250
Objetivo	ARRB1
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P49407
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686 2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886 3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940 4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human ARRB1 Antibody (SAA2250)

Referencias

Datasheet

Anti-Human ARRB1 Recombinant Antibody (SAA2250).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

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