Anti-Human ARRB1 Recombinant Antibody (SAA2250) (HW793013)

Name: Anti-Human ARRB1 Recombinant Antibody (SAA2250)
Brand: abinScience
SKU: HW793013
Price: 191 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HW793013
Reactivité des espèces	Human
Applications	IP
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1
ID de clone	SAA2250
Cible	ARRB1
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P49407
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686 2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886 3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940 4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human ARRB1 Antibody (SAA2250)

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Anti-Human ARRB1 Recombinant Antibody (SAA2250).pdf

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Formula

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