中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HW793013 |
|---|---|
| 種反応性 | Human |
| アプリケーション | IP |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1 |
| クローンID | SAA2250 |
| ターゲット | ARRB1 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P49407 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686 2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886 3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940 4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ARRB1 Antibody (SAA2250)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
