Anti-Human ARRB1 Recombinant Antibody (SAA2250) (HW793013)

Name: Anti-Human ARRB1 Recombinant Antibody (SAA2250)
Brand: abinScience
SKU: HW793013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Даташит
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Обзор

Каталожный номер	HW793013
Реактивность видов	Human
Применения	IP
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	SAA2250
Цель	ARRB1
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P49407
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686 2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886 3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940 4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human ARRB1 Antibody (SAA2250)

Ссылки

Даташит

Anti-Human ARRB1 Recombinant Antibody (SAA2250).pdf

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Formula

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