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Anti-Human ARRB2 Polyclonal Antibody (HB908014)

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Vista general
Número de catálogoHB908014
Descripción
Anti-Human ARRB2 Polyclonal Antibody (HB908014) is a rabbit polyclonal antibody detecting ARRB2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ARRB2 (Met1-Pro368).
Objetivo Beta-arrestin-2, Arrestin beta-2, Non-visual arrestin-3, ARRB2, ARB2, ARR2
Purificación Purified by antigen affinity column.
Número de acceso P32121
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Beta-arrestin-2 (ARRB2) is a ~46 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.

1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686
2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886
3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314
4. Watson, SJ. et al. (2012) Molecular pharmacology 81, 631-42. PMID: 22282525
5. Yan, Y. et al. (2013) Immunity 38, 1154-63. PMID: 23809162
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human ARRB2 Polyclonal Antibody

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