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| カタログ番号 | HB908014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ARRB2 Polyclonal Antibody (HB908014) is a rabbit polyclonal antibody detecting ARRB2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARRB2 (Met1-Pro368). | ||||||||
| ターゲット | Beta-arrestin-2, Arrestin beta-2, Non-visual arrestin-3, ARRB2, ARB2, ARR2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P32121 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Beta-arrestin-2 (ARRB2) is a ~46 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686 2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886 3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314 4. Watson, SJ. et al. (2012) Molecular pharmacology 81, 631-42. PMID: 22282525 5. Yan, Y. et al. (2013) Immunity 38, 1154-63. PMID: 23809162 | ||||||||
| 注意事項 | For research use only. |
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