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| カタログ番号 | HP847013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA0242 | ||||
| ターゲット | ASF1B, hAsf1, hCIA-II, CIA-II, hAsf1b, Histone chaperone ASF1B, Anti-silencing function protein 1 homolog B, CCG1-interacting factor A-II | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NVP2 | ||||
| RRID | Anti-Human ASF1B IP Antibody (SAA0242) (abinScience Cat# HP847013, RRID:AB_3729776) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone chaperone ASF1B is a ~22 kDa protein. Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for gonad development. 1. Mello, JA. et al. (2002) EMBO reports 3, 329-34. PMID: 11897662 2. Tagami, H. et al. (2004) Cell 116, 51-61. PMID: 14718166 3. Groth, A. et al. (2005) Molecular cell 17, 301-11. PMID: 15664198 4. Tamburini, BA. et al. (2005) Eukaryotic cell 4, 1583-90. PMID: 16151251 5. Alvarez, F. et al. (2011) The Journal of biological chemistry 286, 17714-21. PMID: 21454524 6. Campos, EI. et al. (2015) Molecular cell 60, 697-709. PMID: 26527279 7. Campos, EI. et al. (2010) Nature structural & molecular biology 17, 1343-51. PMID: 20953179 8. Umehara, T. et al. (2003) The Journal of biological chemistry 278, 35660-7. PMID: 12842904 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ASF1B IP Antibody (SAA0242)
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