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| カタログ番号 | HF840014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ATG7 Polyclonal Antibody (HF840014) is a rabbit polyclonal antibody detecting ATG7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATG7 (Ser19-Glu321). | ||||||||
| ターゲット | hAGP7, ATG7, Ubiquitin-activating enzyme E1-like protein, APG7L, Ubiquitin-like modifier-activating enzyme ATG7, Autophagy-related protein 7, ATG12-activating enzyme E1 ATG7, APG7-like | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95352 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin-like modifier-activating enzyme ATG7 is a ~77 kDa protein. E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes. 1. Collier, JJ. et al. (2021) The New England journal of medicine 384, 2406-2417. PMID: 34161705 | ||||||||
| 注意事項 | For research use only. |
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