

| Número de catálogo | HD526014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human ATL2 Polyclonal Antibody (HD526014) is a rabbit polyclonal antibody detecting ATL2. Suitable for Mouse and Human.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human ATL2 (Val61-Gly365). | ||||||||
| Objetivo | ADP-ribosylation factor-like protein 6-interacting protein 2, ARL6IP2, ATL-2, ATL2, Atlastin-2, EC:3.6.5.- | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q8NHH9 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Fondo | Atlastin-2 (ATL2) is a ~66 kDa protein. Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). 1. Rismanchi, N. et al. (2008) Human molecular genetics 17, 1591-604. PMID: 18270207 2. Hu, J. et al. (2009) Cell 138, 549-61. PMID: 19665976 3. Morin-Leisk, J. et al. (2011) The Journal of cell biology 195, 605-15. PMID: 22065636 4. Wang, S. et al. (2016) eLife 5. PMID: 27619977 5. Crosby, D. et al. (2022) The Journal of cell biology 221. PMID: 34817557 | ||||||||
| Nota | For research use only |
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