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Anti-Human ATL2 Polyclonal Antibody (HD526014)

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Aperçu
Numéro de catalogueHD526014
Description
Anti-Human ATL2 Polyclonal Antibody (HD526014) is a rabbit polyclonal antibody detecting ATL2. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human ATL2 (Val61-Gly365).
Cible ADP-ribosylation factor-like protein 6-interacting protein 2, ARL6IP2, ATL-2, ATL2, Atlastin-2, EC:3.6.5.-
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès Q8NHH9
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Atlastin-2 (ATL2) is a ~66 kDa protein. Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi).

1. Rismanchi, N. et al. (2008) Human molecular genetics 17, 1591-604. PMID: 18270207
2. Hu, J. et al. (2009) Cell 138, 549-61. PMID: 19665976
3. Morin-Leisk, J. et al. (2011) The Journal of cell biology 195, 605-15. PMID: 22065636
4. Wang, S. et al. (2016) eLife 5. PMID: 27619977
5. Crosby, D. et al. (2022) The Journal of cell biology 221. PMID: 34817557
Note For research use only
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Reférences
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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