

| Numéro de catalogue | HT395014 | ||||||||
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| Description |
Anti-Human ATP10A Polyclonal Antibody (HT395014) is a rabbit polyclonal antibody detecting ATP10A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human ATP10A (Glu688-Arg866). | ||||||||
| Cible | Phospholipid-transporting ATPase VA, 7.6.2.1, ATPase class V type 10A, Aminophospholipid translocase VA, P4-ATPase flippase complex alpha subunit ATP10A, ATP10A, ATP10C, ATPVA, ATPVC, KIAA0566 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O60312 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Phospholipid-transporting ATPase VA (ATP10A) is a ~167 kDa protein. Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer). 1. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375 2. Takada, N. et al. (2018) The EMBO journal 37. PMID: 29599178 3. Roland, BP. et al. (2019) The Journal of biological chemistry 294, 1794-1806. PMID: 30530492 | ||||||||
| Note | For research use only. |
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