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| カタログ番号 | HT395014 | ||||||||
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| 説明 |
Anti-Human ATP10A Polyclonal Antibody (HT395014) is a rabbit polyclonal antibody detecting ATP10A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP10A (Glu688-Arg866). | ||||||||
| ターゲット | Phospholipid-transporting ATPase VA, 7.6.2.1, ATPase class V type 10A, Aminophospholipid translocase VA, P4-ATPase flippase complex alpha subunit ATP10A, ATP10A, ATP10C, ATPVA, ATPVC, KIAA0566 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60312 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid-transporting ATPase VA (ATP10A) is a ~167 kDa protein. Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer). 1. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375 2. Takada, N. et al. (2018) The EMBO journal 37. PMID: 29599178 3. Roland, BP. et al. (2019) The Journal of biological chemistry 294, 1794-1806. PMID: 30530492 | ||||||||
| 注意事項 | For research use only. |
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