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| カタログ番号 | HA160014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ATP13A1 Polyclonal Antibody (HA160014) is a rabbit polyclonal antibody detecting ATP13A1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP13A1 (Ser542-Ser722). | ||||||||
| ターゲット | Endoplasmic reticulum P5A-ATPase, KIAA1825, ATP13A1, Endoplasmic reticulum transmembrane helix translocase, ATP13A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9HD20 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) is a ~132 kDa protein. Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains. 1. McKenna, MJ. et al. (2020) Science (New York, N.Y.) 369. PMID: 32973005 2. Guna, A. et al. (2022) Science (New York, N.Y.) 378, 317-322. PMID: 36264797 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ATP13A1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
Lane 2: Mouse brain lysate
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