

| Numéro de catalogue | HP221014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human ATP5IF1 Polyclonal Antibody (HP221014) is a rabbit polyclonal antibody detecting ATP5IF1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human ATP5IF1 (Met1-Asp106). | ||||||||
| Cible | IF1, Inhibitor of F(1)F(o)-ATPase, ATP synthase F1 subunit epsilon, IF(1), ATP5IF1, ATPI, ATPIF1, ATPase inhibitor, mitochondrial | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9UII2 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | ATPase inhibitor, mitochondrial (ATP5IF1) is a ~12 kDa protein. Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. 1. Wyant, GA. et al. (2022) Science (New York, N.Y.) 377, 621-629. PMID: 35926043 | ||||||||
| Note | For research use only. |
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