Anti-Human ATP6V0D1 Polyclonal Antibody (HX941014)

Name: Anti-Human ATP6V0D1 Polyclonal Antibody
Brand: abinScience
SKU: HX941014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HX941014

Description

Anti-Human ATP6V0D1 Polyclonal Antibody (HX941014) is a rabbit polyclonal antibody detecting ATP6V0D1 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ATP6V0D1 (Met1-Phe351).

Cible

V-ATPase AC39 subunit, V-ATPase subunit d 1, ATP6D, V-type proton ATPase subunit d 1, VPATPD, Vacuolar proton pump subunit d 1, ATP6V0D1, V-ATPase 40 kDa accessory protein, 32 kDa accessory protein, p39

Purification

Purified by antigen affinity column.

Numéro d'accès

P61421

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

V-type proton ATPase subunit d 1 (ATP6V0D1) is a ~40 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.

1. Miles, AL. et al. (2017) eLife 6. PMID: 28296633

2. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053

3. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human ATP6V0D1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human ATP6V0D1 Polyclonal Antibody (HX941014)

Aperçu

Images

Reférences

Fiche technique

SDS