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| カタログ番号 | HX941014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ATP6V0D1 Polyclonal Antibody (HX941014) is a rabbit polyclonal antibody detecting ATP6V0D1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP6V0D1 (Met1-Phe351). | ||||||||
| ターゲット | V-ATPase AC39 subunit, V-ATPase subunit d 1, ATP6D, V-type proton ATPase subunit d 1, VPATPD, Vacuolar proton pump subunit d 1, ATP6V0D1, V-ATPase 40 kDa accessory protein, 32 kDa accessory protein, p39 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61421 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | V-type proton ATPase subunit d 1 (ATP6V0D1) is a ~40 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. 1. Miles, AL. et al. (2017) eLife 6. PMID: 28296633 2. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053 3. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002 | ||||||||
| 注意事項 | For research use only. |
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