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| カタログ番号 | HF937014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP6V1G1 (Met1-Gly118). | ||||||||
| ターゲット | ATP6V1G1, Vacuolar proton pump subunit M16, ATP6G, V-type proton ATPase subunit G 1, Vacuolar proton pump subunit G 1, V-ATPase subunit G 1, V-ATPase 13 kDa subunit 1, ATP6G1, ATP6J | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75348 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | V-type proton ATPase subunit G 1 (ATP6V1G1) is a ~13 kDa protein. Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. 1. Vasanthakumar, T. et al. (2020) Trends in biochemical sciences 45, 295-307. PMID: 32001091 2. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002 3. Miles, AL. et al. (2017) eLife 6. PMID: 28296633 | ||||||||
| 注意事項 | For research use only. |
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