Anti-Human ATR Recombinant Antibody (SAA1672) (HC586013)

Name: Anti-Human ATR Recombinant Antibody (SAA1672)
Brand: abinScience
SKU: HC586013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC586013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1672

Objetivo

FRP1, Serine/threonine-protein kinase ATR, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q13535

RRID

Anti-Human ATR Antibody (SAA1672) (abinScience Cat# HC586013, RRID:AB_3727433)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Serine/threonine-protein kinase ATR is a ~301 kDa protein. Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination.

1. Hall-Jackson, CA. et al. (1999) Oncogene 18, 6707-13. PMID: 10597277

2. Kim, ST. et al. (1999) The Journal of biological chemistry 274, 37538-43. PMID: 10608806

3. Liu, Q. et al. (2000) Genes & development 14, 1448-59. PMID: 10859164

4. Cortez, D. et al. (2001) Science (New York, N.Y.) 294, 1713-6. PMID: 11721054

5. Zou, L. et al. (2003) Science (New York, N.Y.) 300, 1542-8. PMID: 12791985

6. Barr, SM. et al. (2003) Current biology : CB 13, 1047-51. PMID: 12814551

7. Wang, Y. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 15387-92. PMID: 14657349

8. Unsal-Kaçmaz, K. et al. (2004) Molecular and cellular biology 24, 1292-300. PMID: 14729973

9. Ward, IM. et al. (2004) The Journal of biological chemistry 279, 9677-80. PMID: 14742437

10. Cortez, D. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10078-83. PMID: 15210935

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human ATR Antibody (SAA1672)

Referencias

Datasheet

Anti-Human ATR Recombinant Antibody (SAA1672).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo