Anti-Human ATR Recombinant Antibody (SAA1672) (HC586013)

Name: Anti-Human ATR Recombinant Antibody (SAA1672)
Brand: abinScience
SKU: HC586013
Price: 196 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC586013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1672

Cible

FRP1, Serine/threonine-protein kinase ATR, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q13535

RRID

Anti-Human ATR Antibody (SAA1672) (abinScience Cat# HC586013, RRID:AB_3727433)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Serine/threonine-protein kinase ATR is a ~301 kDa protein. Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination.

1. Hall-Jackson, CA. et al. (1999) Oncogene 18, 6707-13. PMID: 10597277

2. Kim, ST. et al. (1999) The Journal of biological chemistry 274, 37538-43. PMID: 10608806

3. Liu, Q. et al. (2000) Genes & development 14, 1448-59. PMID: 10859164

4. Cortez, D. et al. (2001) Science (New York, N.Y.) 294, 1713-6. PMID: 11721054

5. Zou, L. et al. (2003) Science (New York, N.Y.) 300, 1542-8. PMID: 12791985

6. Barr, SM. et al. (2003) Current biology : CB 13, 1047-51. PMID: 12814551

7. Wang, Y. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 15387-92. PMID: 14657349

8. Unsal-Kaçmaz, K. et al. (2004) Molecular and cellular biology 24, 1292-300. PMID: 14729973

9. Ward, IM. et al. (2004) The Journal of biological chemistry 279, 9677-80. PMID: 14742437

10. Cortez, D. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10078-83. PMID: 15210935

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human ATR Antibody (SAA1672)

Reférences

Fiche technique

Anti-Human ATR Recombinant Antibody (SAA1672).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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