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Anti-Human AUP1 Polyclonal Antibody (HV444014)

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Aperçu
Numéro de catalogueHV444014
Description
Anti-Human AUP1 Polyclonal Antibody (HV444014) is a rabbit polyclonal antibody detecting AUP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human AUP1 (Val201-Asp410).
Cible AUP1
Purification Purified by antigen affinity column.
Numéro d'accès Q9Y679
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifsLipid droplet-regulating VLDL assembly factor AUP1, Ancient ubiquitous protein 1, AUP1
Contexte

Lipid droplet-regulating VLDL assembly factor AUP1 is a ~45 kDa protein. Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2.

1. Mueller, B. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12325-30. PMID: 18711132
2. Klemm, EJ. et al. (2011) The Journal of biological chemistry 286, 37602-14. PMID: 21857022
3. Lohmann, D. et al. (2013) PloS one 8, e72453. PMID: 24039768
4. Spandl, J. et al. (2011) The Journal of biological chemistry 286, 5599-606. PMID: 21127063
5. Jo, Y. et al. (2013) Molecular biology of the cell 24, 169-83. PMID: 23223569
6. Zhang, J. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 633-642. PMID: 28183703
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human AUP1 Polyclonal Antibody

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