Anti-Human Axl Polyclonal Antibody (HB709024)

Name: Anti-Human Axl Polyclonal Antibody
Brand: abinScience
SKU: HB709024
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB709024

Descripción

Anti-Human AXL/UFO Polyclonal Antibody (HB709024) is a rabbit polyclonal antibody detecting AXL. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human AXL/UFO (Gly545-Leu810).

Objetivo

AXL, AXL oncogene, EC:2.7.10.1, Tyrosine-protein kinase receptor UFO, UFO

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P30530

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.

Nota

For research use only

Imágenes

Referencias

Datasheet