Anti-Human BACE2 Polyclonal Antibody (HV256014)

Name: Anti-Human BACE2 Polyclonal Antibody
Brand: abinScience
SKU: HV256014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HV256014

Description

Anti-Human BACE2 Polyclonal Antibody (HV256014) is a rabbit polyclonal antibody detecting BACE2. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human BACE2 (Phe77-Ser445).

Cible

AEPLC, ALP56, ASP1, ASP21, Asp 1, Aspartic-like protease 56 kDa, Aspartyl protease 1, BACE2, Beta-secretase 2, Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, DRAP, Down region aspartic protease, EC:3.4.23.45, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y5Z0

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.

1. Yan, R. et al. (1999) Nature 402, 533-7. PMID: 10591213

2. Hussain, I. et al. (2000) Molecular and cellular neurosciences 16, 609-19. PMID: 11083922

3. Yan, R. et al. (2001) The Journal of biological chemistry 276, 34019-27. PMID: 11423558

4. Sun, X. et al. (2005) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 739-49. PMID: 15857888

5. Sun, X. et al. (2006) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 1369-76. PMID: 16816112

6. Rochin, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10658-63. PMID: 23754390

7. Esterházy, D. et al. (2011) Cell metabolism 14, 365-77. PMID: 21907142

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human BACE2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human BACE2 Polyclonal Antibody (HV256014)

Aperçu

Images

Reférences

Fiche technique

SDS