Anti-Human BACE2 Polyclonal Antibody (HV256014)

Name: Anti-Human BACE2 Polyclonal Antibody
Brand: abinScience
SKU: HV256014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Обзор

Каталожный номер

HV256014

Описание

Anti-Human BACE2 Polyclonal Antibody (HV256014) is a rabbit polyclonal antibody detecting BACE2. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human BACE2 (Phe77-Ser445).

Цель

AEPLC, ALP56, ASP1, ASP21, Asp 1, Aspartic-like protease 56 kDa, Aspartyl protease 1, BACE2, Beta-secretase 2, Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, DRAP, Down region aspartic protease, EC:3.4.23.45, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

Q9Y5Z0

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Фон

Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.

1. Yan, R. et al. (1999) Nature 402, 533-7. PMID: 10591213

2. Hussain, I. et al. (2000) Molecular and cellular neurosciences 16, 609-19. PMID: 11083922

3. Yan, R. et al. (2001) The Journal of biological chemistry 276, 34019-27. PMID: 11423558

4. Sun, X. et al. (2005) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 739-49. PMID: 15857888

5. Sun, X. et al. (2006) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 1369-76. PMID: 16816112

6. Rochin, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10658-63. PMID: 23754390

7. Esterházy, D. et al. (2011) Cell metabolism 14, 365-77. PMID: 21907142

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Human BACE2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human BACE2 Polyclonal Antibody (HV256014)

Обзор

Изображения

Ссылки

Даташит

SDS