Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

Name: Anti-Human BAG3 Recombinant Antibody (SAA0529), APC
Brand: abinScience
SKU: HF640137
Price: 214 USD
Availability: InStock

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Número de catálogo	HF640137
Reactividad de especies	Human
Aplicaciones	ELISA, FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	SAA0529
Conjugación	APC
Objetivo	Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
Nivel de endotoxinas	Please contact with the lab for this information.
Número de acceso	O95817
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). 1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606 2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338 3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739 4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016 5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216 6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human BAG3 Recombinant Antibody (SAA0529), APC.pdf

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