Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

Name: Anti-Human BAG3 Recombinant Antibody (SAA0529), APC
Brand: abinScience
SKU: HF640137
Price: 214 USD
Availability: InStock

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概要

カタログ番号	HF640137
種反応性	Human
アプリケーション	ELISA, FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG2a, kappa
クローンID	SAA0529
抱合	APC
ターゲット	Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
エンドトキシンレベル	Please contact with the lab for this information.
アクセッション番号	O95817
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). 1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606 2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338 3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739 4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016 5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216 6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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データシート

Anti-Human BAG3 Recombinant Antibody (SAA0529), APC.pdf

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Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

概要

イメージ

参考文献

データシート

SDS

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