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| カタログ番号 | HP018014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BHLHE41 (Asp40-Leu174). | ||||||||
| ターゲット | bHLHe41, hDEC2, DEC2, bHLHb3, Enhancer-of-split and hairy-related protein 1, Class E basic helix-loop-helix protein 41, Class B basic helix-loop-helix protein 3, BHLHB3, SHARP1, SHARP-1, Differentially expressed in chondrocytes protein 2, BHLHE41 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9C0J9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Class E basic helix-loop-helix protein 41 (BHLHE41) is a ~50 kDa protein. Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. 1. Garriga-Canut, M. et al. (2001) The Journal of biological chemistry 276, 14821-8. PMID: 11278948 2. Kawamoto, T. et al. (2004) Biochemical and biophysical research communications 313, 117-24. PMID: 14672706 3. Li, Y. et al. (2004) The Biochemical journal 382, 895-904. PMID: 15193144 4. Sato, F. et al. (2004) European journal of biochemistry 271, 4409-19. PMID: 15560782 5. Nakashima, A. et al. (2008) Molecular and cellular biology 28, 4080-92. PMID: 18411297 6. Cho, Y. et al. (2009) Molecular pharmacology 76, 1360-9. PMID: 19786558 7. Pellegrino, R. et al. (2014) Sleep 37, 1327-36. PMID: 25083013 | ||||||||
| 注意事項 | For research use only. |
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