Anti-Human BMP2 Recombinant Antibody (SAA0423), PE (HY576127)

Name: Anti-Human BMP2 Recombinant Antibody (SAA0423), PE
Brand: abinScience
SKU: HY576127
Price: 256 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HY576127
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA0423
Conjugaison	PE
Cible	BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Numéro d'accès	P12643
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. 1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533 2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451 3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241 5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755 6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905 7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754 8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using PE anti-human BMP2 antibody. Hela cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human BMP2 monoclonal antibody (Catalog: HY576127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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Anti-Human BMP2 Recombinant Antibody (SAA0423), PE.pdf

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