Anti-Human BMP6 Recombinant Antibody (SAA0425), PE (HB857127)

Name: Anti-Human BMP6 Recombinant Antibody (SAA0425), PE
Brand: abinScience
SKU: HB857127
Price: 256 USD
Availability: InStock

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Каталожный номер	HB857127
Реактивность видов	Human
Применения	ELISA, FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	SAA0425
Конъюгация	PE
Цель	VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Номер доступа	P22004
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. 1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087 3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108 6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human BMP6 Recombinant Antibody (SAA0425), PE.pdf

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