

| Numéro de catalogue | HF006014 | ||||||||
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| Description |
Anti-Human BPNT1 Polyclonal Antibody (HF006014) is a rabbit polyclonal antibody detecting BPNT1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human BPNT1 (Met1-Pro308). | ||||||||
| Cible | 3'(2'), 5'-bisphosphate nucleotidase 1, 3.1.3.7, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase, Bisphosphate 3'-nucleotidase 1, BPntase 1, HsPIP, Inositol-polyphosphate 1-phosphatase, 3.1.3.57, BPNT1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O95861 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) is a ~33 kDa protein. Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate. Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate. 1. Yenush, L. et al. (2000) FEBS letters 467, 321-5. PMID: 10675562 | ||||||||
| Note | For research use only. |
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