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| カタログ番号 | HF006014 | ||||||||
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| 説明 |
Anti-Human BPNT1 Polyclonal Antibody (HF006014) is a rabbit polyclonal antibody detecting BPNT1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BPNT1 (Met1-Pro308). | ||||||||
| ターゲット | 3'(2'), 5'-bisphosphate nucleotidase 1, 3.1.3.7, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase, Bisphosphate 3'-nucleotidase 1, BPntase 1, HsPIP, Inositol-polyphosphate 1-phosphatase, 3.1.3.57, BPNT1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95861 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) is a ~33 kDa protein. Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate. Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate. 1. Yenush, L. et al. (2000) FEBS letters 467, 321-5. PMID: 10675562 | ||||||||
| 注意事項 | For research use only. |
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