Anti-Human BRD2 IP Recombinant Antibody (SAA0190) (HB192013)

Name: Anti-Human BRD2 IP Recombinant Antibody (SAA0190)
Brand: abinScience
SKU: HB192013
Price: 126 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB192013

Reactividad de especies

Human

Aplicaciones

ELISA, IF, IP, IP-MS

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA0190

Objetivo

Really interesting new gene 3 protein, KIAA9001, O27.1.1, BRD2, RING3, Bromodomain-containing protein 2

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P25440

RRID

Anti-Human BRD2 IP Antibody (SAA0190) (abinScience Cat# HB192013, RRID:AB_3729724)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Bromodomain-containing protein 2 (BRD2) is a ~88 kDa protein. Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin.

1. Nakamura, Y. et al. (2007) The Journal of biological chemistry 282, 4193-201. PMID: 17148447

2. Huang, H. et al. (2007) BMC structural biology 7, 57. PMID: 17848202

3. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326

4. Umehara, T. et al. (2010) The Journal of biological chemistry 285, 7610-8. PMID: 20048151

5. Umehara, T. et al. (2010) FEBS letters 584, 3901-8. PMID: 20709061

6. Filippakopoulos, P. et al. (2010) Nature 468, 1067-73. PMID: 20871596

7. Cheung, KL. et al. (2017) Molecular cell 65, 1068-1080.e5. PMID: 28262505

8. Xie, L. et al. (2022) Nature genetics 54, 481-491. PMID: 35410381

Nota

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human BRD2 IP Antibody (SAA0190)

Referencias

Datasheet

Anti-Human BRD2 IP Recombinant Antibody (SAA0190).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo