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| カタログ番号 | HT193014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human BUB3 Polyclonal Antibody (HT193014) is a rabbit polyclonal antibody detecting BUB3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BUB3 (Met1-Thr328). | ||||||||
| ターゲット | Mitotic checkpoint protein BUB3, BUB3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43684 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitotic checkpoint protein BUB3 is a ~37 kDa protein. Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-BUB3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
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