Anti-Human Complement Component C5aR1 Polyclonal Antibody (HB064024)

Name: Anti-Human Complement Component C5aR1 Polyclonal Antibody
Brand: abinScience
SKU: HB064024
Price: 168 USD
Availability: InStock

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50ug
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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB064024

Descripción

Anti-Human C5AR1 Polyclonal Antibody (HB064024) is a rabbit polyclonal antibody detecting C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD88; C5AR1; C5AR; C5R1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human C5AR1 (Arg175-Arg206).

Objetivo

C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD88; C5AR1; C5AR; C5R1

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P21730

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

C5a anaphylatoxin chemotactic receptor 1 (C5AR1) is a ~39 kDa protein. Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.

1. Christophe, T. et al. (2000) The Journal of biological chemistry 275, 1656-64. PMID: 10636859

2. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520

3. Gerard, NP. et al. (1991) Nature 349, 614-7. PMID: 1847994

4. Robertson, N. et al. (2018) Nature 553, 111-114. PMID: 29300009

5. Feng, Y. et al. (2023) Cell research 33, 312-324. PMID: 36806352

6. Monk, PN. et al. (1995) The Journal of biological chemistry 270, 16625-9. PMID: 7622471

7. DeMartino, JA. et al. (1994) The Journal of biological chemistry 269, 14446-50. PMID: 8182049

8. Chen, Z. et al. (1998) The Journal of biological chemistry 273, 10411-9. PMID: 9553099

9. Yadav, MK. et al. (2023) Cell 186, 4956-4973.e21. PMID: 37852260

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human Complement Component C5aR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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