中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY181013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1569 | ||||
| ターゲット | C7, Complement component C7 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P10643 | ||||
| RRID | Anti-Human C7 Antibody (SAA1569) (abinScience Cat# HY181013, RRID:AB_3727330) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Complement component C7 (Complement C7) is a ~93 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending. 1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 3. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 4. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 5. DiScipio, RG. et al. (1988) The Journal of biological chemistry 263, 549-60. PMID: 3335508 6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human C7 Antibody (SAA1569)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
