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| カタログ番号 | HY173014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human C8A Polyclonal Antibody (HY173014) is a rabbit polyclonal antibody detecting C8A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human C8A (Ala135-Arg498). | ||||||||
| ターゲット | Complement component C8 alpha chain, Complement component 8 subunit alpha, C8A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07357 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complement component C8 alpha chain (C8A) is a ~65 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8A, together with C8B and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity. 1. Hadders, MA. et al. (2007) Science (New York, N.Y.) 317, 1552-4. PMID: 17872444 2. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 3. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 6. Steckel, EW. et al. (1980) The Journal of biological chemistry 255, 11997-2005. PMID: 7440581 7. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 8. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 9. Steckel, EW. et al. (1983) The Journal of biological chemistry 258, 4318-24. PMID: 6833260 | ||||||||
| 注意事項 | For research use only. |
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