Anti-Human CACNA1C Recombinant Antibody (L57/46R) (HC588023)

Name: Anti-Human CACNA1C Recombinant Antibody (L57/46R)
Brand: abinScience
SKU: HC588023
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC588023

Reactividad de especies

Human

Aplicaciones

IHC, IP, WB

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a

ID de clon

L57/46R

Objetivo

Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1, Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Rat brain class C, RBC, Voltage-gated calcium channel subunit alpha Cav1.2

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q13936

RRID

Anti-Human CACNA1C Antibody (L57/46R) (abinScience Cat# HC588023, RRID:AB_3726995)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine.

1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 12181424

2. Splawski, I. et al. (2004) Cell 119, 19-31. PMID: 15454078

3. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 15863612

4. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 16299511

5. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 17224476

6. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 20953164

7. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 23677916

8. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 24728418

9. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 26253506

10. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CACNA1C Antibody (L57/46R)

Referencias

Datasheet

Anti-Human CACNA1C Recombinant Antibody (L57/46R).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo