中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC588023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | IHC, IP, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | L57/46R | ||||
| ターゲット | Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1, Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Rat brain class C, RBC, Voltage-gated calcium channel subunit alpha Cav1.2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q13936 | ||||
| RRID | Anti-Human CACNA1C Antibody (L57/46R) (abinScience Cat# HC588023, RRID:AB_3726995) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. 1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 12181424 2. Splawski, I. et al. (2004) Cell 119, 19-31. PMID: 15454078 3. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 15863612 4. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 16299511 5. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 17224476 6. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 20953164 7. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 23677916 8. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 24728418 9. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 26253506 10. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CACNA1C Antibody (L57/46R)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
