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| カタログ番号 | HS841107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2, lambda |
| クローンID | SAA0150 |
| ターゲット | CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q16602 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864 3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685 4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CALCRL Antibody (SAA0150)
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