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| カタログ番号 | HW596014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CAMLG Polyclonal Antibody (HW596014) is a rabbit polyclonal antibody detecting CAMLG in ELISA, IHC, WB. Suitable for Mus musculus and Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CAMLG (Gly19-Glu184). | ||||||||
| ターゲット | CAMLG | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P49069 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Guided entry of tail-anchored proteins factor CAMLG, Calcium signal-modulating cyclophilin ligand, CAMLG, CAML, GET2 | ||||||||
| 背景 | Guided entry of tail-anchored proteins factor CAMLG is a ~32 kDa protein. Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. 1. Yamamoto, Y. et al. (2012) Molecular cell 48, 387-97. PMID: 23041287 2. Vilardi, F. et al. (2014) PloS one 9, e85033. PMID: 24392163 3. Colombo, SF. et al. (2016) The Journal of biological chemistry 291, 15292-306. PMID: 27226539 4. Inglis, AJ. et al. (2020) Cell reports 30, 3691-3698.e5. PMID: 32187542 5. Bram, RJ. et al. (1994) Nature 371, 355-8. PMID: 7522304 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CAMLG polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: 293T cell lysate
Lane 3: Mouse testis lysate
Lane 4: Mouse brain lysate
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