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| カタログ番号 | HB643014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CASQ1 Polyclonal Antibody (HB643014) is a rabbit polyclonal antibody detecting CASQ1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CASQ1 (Asn56-Asp396). | ||||||||
| ターゲット | Calsequestrin, skeletal muscle isoform, CASQ, Calmitine, CASQ1, Calsequestrin-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31415 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Calsequestrin-1 (CASQ1) is a ~45 kDa protein. Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity. 1. Barone, V. et al. (2017) Human mutation 38, 1761-1773. PMID: 28895244 2. Zhang, L. et al. (2016) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 38, 2183-93. PMID: 27185316 | ||||||||
| 注意事項 | For research use only. |
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