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| カタログ番号 | HW451014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CBS Polyclonal Antibody (HW451014) is a rabbit polyclonal antibody detecting CBS in ELISA, IHC, WB. Suitable for Human, Mouse, and Macaca fascicularis.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CBS (Lys72-Lys551). | ||||||||
| ターゲット | Serine sulfhydrase, CBS, Cystathionine beta-synthase, Beta-thionase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35520 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cystathionine beta-synthase (CBS) is a ~60 kDa protein. Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. 1. Kozich, V. et al. (2010) Human mutation 31, 809-19. PMID: 20506325 2. Mendes, MI. et al. (2014) Journal of inherited metabolic disease 37, 245-54. PMID: 23974653 3. Casique, L. et al. (2013) Gene 531, 117-24. PMID: 23981774 | ||||||||
| 注意事項 | For research use only. |
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