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| カタログ番号 | HT334013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | P004 | ||||
| ターゲット | CBX4, E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O00257 | ||||
| RRID | Anti-Human CBX4 Antibody (P004) (abinScience Cat# HT334013, RRID:AB_3729487) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | E3 SUMO-protein ligase CBX4 is a ~61 kDa protein. E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate. Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain. Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation. Monosumoylates ZNF131. 1. Kagey, MH. et al. (2003) Cell 113, 127-37. PMID: 12679040 2. Oh, Y. et al. (2012) The Journal of biological chemistry 287, 17517-17529. PMID: 22467880 3. Pelisch, F. et al. (2012) The Journal of biological chemistry 287, 30789-99. PMID: 22825850 4. Levine, SS. et al. (2002) Molecular and cellular biology 22, 6070-8. PMID: 12167701 5. Maertens, GN. et al. (2009) PloS one 4, e6380. PMID: 19636380 6. Vandamme, J. et al. (2011) Molecular & cellular proteomics : MCP 10, M110.002642. PMID: 21282530 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CBX4 Antibody (P004)
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