

| Каталожный номер | HF624014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human CBX6 Polyclonal Antibody (HF624014) is a rabbit polyclonal antibody detecting CBX6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CBX6 (Met1-Lys412). | ||||||||
| Цель | Chromobox protein homolog 6, CBX6 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O95503 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Chromobox protein homolog 6 (CBX6) is a ~43 kDa protein. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells. 1. Vandamme, J. et al. (2011) Molecular & cellular proteomics : MCP 10, M110.002642. PMID: 21282530 2. Vincenz, C. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 16572-7. PMID: 18927235 | ||||||||
| Примечание | For research use only. |
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