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Anti-Human CCDC22 Polyclonal Antibody (HF586014)

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Vista general
Número de catálogoHF586014
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CCDC22 (Met1-Arg107).
Objetivo Coiled-coil domain-containing protein 22, CCDC22, CXorf37
Purificación Purified by antigen affinity column.
Número de acceso O60826
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Coiled-coil domain-containing protein 22 (CCDC22) is a ~70 kDa protein. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex.

1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566
2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129
3. Starokadomskyy, P. et al. (2013) The Journal of clinical investigation 123, 2244-56. PMID: 23563313
4. Phillips-Krawczak, CA. et al. (2015) Molecular biology of the cell 26, 91-103. PMID: 25355947
5. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human CCDC22 Polyclonal Antibody

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