Anti-Human CCDC22 Polyclonal Antibody (HF586014)

Name: Anti-Human CCDC22 Polyclonal Antibody
Brand: abinScience
SKU: HF586014
Price: 168 USD
Availability: InStock

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HF586014

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CCDC22 (Met1-Arg107).

Цель

Coiled-coil domain-containing protein 22, CCDC22, CXorf37

Очистка

Purified by antigen affinity column.

Номер доступа

O60826

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Coiled-coil domain-containing protein 22 (CCDC22) is a ~70 kDa protein. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex.

1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566

2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129

3. Starokadomskyy, P. et al. (2013) The Journal of clinical investigation 123, 2244-56. PMID: 23563313

4. Phillips-Krawczak, CA. et al. (2015) Molecular biology of the cell 26, 91-103. PMID: 25355947

5. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human CCDC22 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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