Anti-Human CD106/VCAM1 Recombinant Antibody (H6), APC (HB032237)

Name: Anti-Human CD106/VCAM1 Recombinant Antibody (H6), APC
Brand: abinScience
SKU: HB032237
Price: 290 USD
Availability: InStock

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Vista general

Número de catálogo	HB032237
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Rabbit
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	H6
Conjugación	APC
Objetivo	Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Rabbit IgG Recombinant Isotype Control Antibody (HyHEL-10), APC
Número de acceso	P19320
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. 1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649 2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034 3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700 4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD106/VCAM1 Recombinant Antibody (H6), APC.pdf

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