Anti-Human CD106/VCAM1 Recombinant Antibody (H6), PE (HB032227)

Name: Anti-Human CD106/VCAM1 Recombinant Antibody (H6), PE
Brand: abinScience
SKU: HB032227
Price: 290 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HB032227
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Rabbit
Clonalité	Monoclonal
Isotype	IgG
ID de clone	H6
Conjugaison	PE
Cible	Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Rabbit IgG Recombinant Isotype Control Antibody (HyHEL-10), PE
Numéro d'accès	P19320
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. 1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649 2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034 3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700 4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD106/VCAM1 Recombinant Antibody (H6), PE.pdf

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