中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB032023 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human CD106/VCAM1 Nanobody (cAbVCAM1-5) [cAbVCAM1-5] (HB032023) is a alpaca monoclonal antibody detecting VCAM1 in ELISA, FuncS. Suitable for Human and Mouse.
|
||||
| 種反応性 | Human, Mouse | ||||
| アプリケーション | ELISA, FuncS | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-8His-Cys-tag | ||||
| クローンID | cAbVCAM1-5 | ||||
| ターゲット | Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by Nickel column. | ||||
| アクセッション番号 | P19320 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. 1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649 2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034 3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700 4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD106/VCAM1 Nanobody (cAbVCAM1-5)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
