Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), PerCP (HY332147)

Name: Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), PerCP
Brand: abinScience
SKU: HY332147
Price: 196 USD
Availability: InStock

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Numéro de catalogue	HY332147
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	Mab1
Conjugaison	PerCP
Cible	LAMP1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PerCP
Numéro d'accès	P11279
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. 1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921 3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890 4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195 5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.